Publications

Below you will find a summary on key recent publications. Further information on publications please refer to links associated with collaboration members. 

Computed tomography‐defined low skeletal muscle index and density in cancer patients: observations from a systematic review. McGovern et al. Journal of Cachexia Sarcopenia and Muscle. 

A systemic review of the prevalence of low skeletal muscle mass and density in patients with common solid organ tumours. Poor muscle status was found to be endemic across a range of cancer types and disease stage, challenging pre-existing dogma of the determinants of prevalence

A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer. Hall et al. Journal of Cachexia, Sarcopenia and Muscle

This phase 2 trial demonstrated that an exercise and nutrition based intervention in people with advanced cancer was feasible, improved aspects of quality of life and was potentially cost-saving. 

Relationship between cytokines and symptoms in people with incurable cancer: A systematic review. Patton & Paval et al.

IL-6, TNF-α and IL-8 were associated with the development of cancer cachexia and their levels were constantly higher in cachectic patients compared to healthy individuals. The available body of literature could not be meta-analysed due to the high degree of methodological heterogeneity. Future research should aim to use longitudinal designs, group participants using established definitions (Fearon definition or mGPS), include surrogate markers (i.e. acute-phase proteins and cytokine receptors) and increase transparency in data reporting. 

ESPEN Practical Guideline: Clinical Nutrition in Cancer. 

This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients and gives guidance to health care providers involved in the management of cancer patients to offer optimal nutritional care.

A systematic review examining cytokines in cachexia

This extensive systematic review shows that IL-6, TNF-α, and IL-8 were greater in cachectic patients compared with healthy individuals. Also, IL-6 levels were higher in cachectic participants as opposed to non-cachectic patients. Leptin, interferon-γ, IL-1β, IL-10, adiponectin, and ghrelin did not demonstrate any significant difference between groups when individuals with cancer cachexia were compared against non-cachectic patients or healthy participants.